Determination of antibodies in everyday rheumatological practice
Identifieur interne : 000893 ( Main/Exploration ); précédent : 000892; suivant : 000894Determination of antibodies in everyday rheumatological practice
Auteurs : Katarzyna Napi Rkowska-Baran [Pologne] ; Joanna Zalewska [Pologne] ; Sławomir Jeka [Pologne] ; Iwona Dankiewicz-Fares [Pologne] ; Marcin Zi Tkiewicz [Pologne] ; Ewa Szynkiewicz [Pologne] ; Sylwia Kołtan [Pologne] ; Adam Wawrze Czyk [Pologne] ; Ewa Wi Sik-Szewczyk [Pologne] ; Zbigniew Bartuzi [Pologne]Source :
- Reumatologia [ 0034-6233 ] ; 2019.
Abstract
Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the γ-globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.
Url:
DOI: 10.5114/reum.2019.84814
PubMed: 31130747
PubMed Central: 6532108
Affiliations:
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level="a" type="main">Determination of antibodies in everyday rheumatological practice</title><author><name sortKey="Napi Rkowska Baran, Katarzyna" sort="Napi Rkowska Baran, Katarzyna" uniqKey="Napi Rkowska Baran K" first="Katarzyna" last="Napi Rkowska-Baran">Katarzyna Napi Rkowska-Baran</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Zalewska, Joanna" sort="Zalewska, Joanna" uniqKey="Zalewska J" first="Joanna" last="Zalewska">Joanna Zalewska</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Jeka, Slawomir" sort="Jeka, Slawomir" uniqKey="Jeka S" first="Sławomir" last="Jeka">Sławomir Jeka</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Dankiewicz Fares, Iwona" sort="Dankiewicz Fares, Iwona" uniqKey="Dankiewicz Fares I" first="Iwona" last="Dankiewicz-Fares">Iwona Dankiewicz-Fares</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Zi Tkiewicz, Marcin" sort="Zi Tkiewicz, Marcin" uniqKey="Zi Tkiewicz M" first="Marcin" last="Zi Tkiewicz">Marcin Zi Tkiewicz</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk</wicri:regionArea><wicri:noRegion>Medical University of Gdansk</wicri:noRegion></affiliation></author><author><name sortKey="Szynkiewicz, Ewa" sort="Szynkiewicz, Ewa" uniqKey="Szynkiewicz E" first="Ewa" last="Szynkiewicz">Ewa Szynkiewicz</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Koltan, Sylwia" sort="Koltan, Sylwia" uniqKey="Koltan S" first="Sylwia" last="Kołtan">Sylwia Kołtan</name><affiliation wicri:level="1"><nlm:aff id="aff0004">Department of Paediatrics, Haematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Paediatrics, Haematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Wawrze Czyk, Adam" sort="Wawrze Czyk, Adam" uniqKey="Wawrze Czyk A" first="Adam" last="Wawrze Czyk">Adam Wawrze Czyk</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author><author><name sortKey="Wi Sik Szewczyk, Ewa" sort="Wi Sik Szewczyk, Ewa" uniqKey="Wi Sik Szewczyk E" first="Ewa" last="Wi Sik-Szewczyk">Ewa Wi Sik-Szewczyk</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Internal Medicine, Pneumonology, Allergology, and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Internal Medicine, Pneumonology, Allergology, and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Bartuzi, Zbigniew" sort="Bartuzi, Zbigniew" uniqKey="Bartuzi Z" first="Zbigniew" last="Bartuzi">Zbigniew Bartuzi</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun</wicri:regionArea><wicri:noRegion>Nicolaus Copernicus University in Torun</wicri:noRegion></affiliation></author></analytic><series><title level="j">Reumatologia</title><idno type="ISSN">0034-6233</idno><idno type="eISSN">2084-9834</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the γ-globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yazdani, R" uniqKey="Yazdani R">R Yazdani</name></author><author><name sortKey="Azizi, G" uniqKey="Azizi G">G Azizi</name></author><author><name sortKey="Abolhassani, H" uniqKey="Abolhassani H">H Abolhassani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novaretti, Mcz" uniqKey="Novaretti M">MCZ Novaretti</name></author><author><name sortKey="Dinardo, Cl" uniqKey="Dinardo C">CL Dinardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierpont, Tm" uniqKey="Pierpont T">TM Pierpont</name></author><author><name sortKey="Limper, Cb" uniqKey="Limper C">CB Limper</name></author><author><name sortKey="Richards, Kl" uniqKey="Richards K">KL Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Domingo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorenzo, Pr" uniqKey="Lorenzo P">PR Lorenzo</name></author><author><name sortKey="Kuwabara, N" uniqKey="Kuwabara N">N Kuwabara</name></author><author><name sortKey="Kondo, N" uniqKey="Kondo N">N Kondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bakry, Oa" uniqKey="Bakry O">OA Bakry</name></author><author><name sortKey="El Shazly, Rm" uniqKey="El Shazly R">RM El Shazly</name></author><author><name sortKey="Basha, Ma" uniqKey="Basha M">MA Basha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellis, Ak" uniqKey="Ellis A">AK Ellis</name></author><author><name sortKey="Waserman, S" uniqKey="Waserman S">S Waserman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogensen, Th" uniqKey="Mogensen T">TH Mogensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felgentreff, K" uniqKey="Felgentreff K">K Felgentreff</name></author><author><name sortKey="Siepe, M" uniqKey="Siepe M">M Siepe</name></author><author><name sortKey="Kotthoff, S" uniqKey="Kotthoff S">S Kotthoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopes, I" uniqKey="Lopes I">I Lopes</name></author><author><name sortKey="Marques, L" uniqKey="Marques L">L Marques</name></author><author><name sortKey="Neves, E" uniqKey="Neves E">E Neves</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Napi Rkowska Baran, Katarzyna" sort="Napi Rkowska Baran, Katarzyna" uniqKey="Napi Rkowska Baran K" first="Katarzyna" last="Napi Rkowska-Baran">Katarzyna Napi Rkowska-Baran</name></noRegion><name sortKey="Bartuzi, Zbigniew" sort="Bartuzi, Zbigniew" uniqKey="Bartuzi Z" first="Zbigniew" last="Bartuzi">Zbigniew Bartuzi</name><name sortKey="Dankiewicz Fares, Iwona" sort="Dankiewicz Fares, Iwona" uniqKey="Dankiewicz Fares I" first="Iwona" last="Dankiewicz-Fares">Iwona Dankiewicz-Fares</name><name sortKey="Jeka, Slawomir" sort="Jeka, Slawomir" uniqKey="Jeka S" first="Sławomir" last="Jeka">Sławomir Jeka</name><name sortKey="Koltan, Sylwia" sort="Koltan, Sylwia" uniqKey="Koltan S" first="Sylwia" last="Kołtan">Sylwia Kołtan</name><name sortKey="Szynkiewicz, Ewa" sort="Szynkiewicz, Ewa" uniqKey="Szynkiewicz E" first="Ewa" last="Szynkiewicz">Ewa Szynkiewicz</name><name sortKey="Wawrze Czyk, Adam" sort="Wawrze Czyk, Adam" uniqKey="Wawrze Czyk A" first="Adam" last="Wawrze Czyk">Adam Wawrze Czyk</name><name sortKey="Wi Sik Szewczyk, Ewa" sort="Wi Sik Szewczyk, Ewa" uniqKey="Wi Sik Szewczyk E" first="Ewa" last="Wi Sik-Szewczyk">Ewa Wi Sik-Szewczyk</name><name sortKey="Zalewska, Joanna" sort="Zalewska, Joanna" uniqKey="Zalewska J" first="Joanna" last="Zalewska">Joanna Zalewska</name><name sortKey="Zi Tkiewicz, Marcin" sort="Zi Tkiewicz, Marcin" uniqKey="Zi Tkiewicz M" first="Marcin" last="Zi Tkiewicz">Marcin Zi Tkiewicz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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